Martin Reck Selected Research

Pemetrexed (MTA)

10/2020	Updated Analysis From KEYNOTE-189: Pembrolizumab or Placebo Plus Pemetrexed and Platinum for Previously Untreated Metastatic Nonsquamous Non-Small-Cell Lung Cancer.
1/2020	Patient-reported outcomes following pembrolizumab or placebo plus pemetrexed and platinum in patients with previously untreated, metastatic, non-squamous non-small-cell lung cancer (KEYNOTE-189): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial.
1/2019	Nintedanib in combination with pemetrexed and cisplatin for chemotherapy-naive patients with advanced malignant pleural mesothelioma (LUME-Meso): a double-blind, randomised, placebo-controlled phase 3 trial.
1/2018	Evaluation of changes in renal function in PARAMOUNT: a phase III study of maintenance pemetrexed plus best supportive care versus placebo plus best supportive care after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer.
11/2017	Nintedanib Plus Pemetrexed/Cisplatin in Patients With Malignant Pleural Mesothelioma: Phase II Results From the Randomized, Placebo-Controlled LUME-Meso Trial.
1/2017	An Open-Label, Multicenter, Randomized, Phase II Study of Cisplatin and Pemetrexed With or Without Cixutumumab (IMC-A12) as a First-Line Therapy in Patients With Advanced Nonsquamous Non-Small Cell Lung Cancer.
1/2017	LUME-Meso: Design and Rationale of the Phase III Part of a Placebo-Controlled Study of Nintedanib and Pemetrexed/Cisplatin Followed by Maintenance Nintedanib in Patients With Unresectable Malignant Pleural Mesothelioma.
1/2017	65Plus: open-label study of bevacizumab in combination with pemetrexed or pemetrexed/carboplatin as first-line treatment of patients with advanced or recurrent nonsquamous non-small-cell lung cancer.
12/2015	A randomized Phase 2 study of pemetrexed in combination with cisplatin or carboplatin as adjuvant chemotherapy in patients with completely resected stage IB or II Non-Small-Cell Lung Cancer.
9/2015	Phase I Study of Lapatinib and Pemetrexed in the Second-Line Treatment of Advanced or Metastatic Non-Small-Cell Lung Cancer With Assessment of Circulating Cell Free Thymidylate Synthase RNA as a Potential Biomarker.

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Martin Reck Research Topics

Disease

183	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2022 - 03/2005
98	Neoplasms (Cancer) 03/2022 - 10/2003
47	Disease Progression 04/2022 - 10/2005
41	Lung Neoplasms (Lung Cancer) 03/2022 - 08/2006
20	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2022 - 01/2003
18	Neutropenia 01/2021 - 03/2007
17	Adenocarcinoma 10/2020 - 10/2007
11	Exanthema (Rash) 01/2022 - 11/2008
10	Neoplasm Metastasis (Metastasis) 01/2022 - 06/2012
10	Brain Neoplasms (Brain Tumor) 01/2022 - 10/2012
9	Febrile Neutropenia 01/2020 - 03/2007
7	Thrombocytopenia (Thrombopenia) 06/2016 - 09/2006
6	Fatigue 10/2020 - 03/2012
6	Malignant Mesothelioma 01/2019 - 04/2005
6	Diarrhea 11/2016 - 05/2006
6	Anemia 12/2014 - 03/2007
5	Pain (Aches) 10/2020 - 08/2006
5	Melanoma (Melanoma, Malignant) 05/2019 - 06/2012
4	Cough 10/2020 - 08/2006
4	Hypertension (High Blood Pressure) 01/2020 - 08/2014
4	Nausea 01/2018 - 11/2011
4	Sepsis (Septicemia) 02/2014 - 03/2010
3	Adenocarcinoma of Lung 02/2022 - 01/2016
3	Body Weight (Weight, Body) 12/2018 - 07/2015
3	Mesothelioma 01/2017 - 04/2005
3	Hemorrhage 10/2012 - 09/2009
2	COVID-19 01/2022 - 01/2020
2	Asthenia 01/2021 - 06/2012
2	Carcinogenesis 01/2021 - 01/2009
2	Dyspnea (Shortness of Breath) 10/2020 - 08/2006
2	Dermatitis 12/2019 - 06/2012
2	Pneumonia (Pneumonitis) 12/2019 - 02/2014
2	Ovarian Neoplasms (Ovarian Cancer) 10/2019 - 05/2015
2	Circulating Neoplastic Cells 06/2019 - 12/2013
2	Fibrosis (Cirrhosis) 01/2019 - 01/2018
2	Renal Cell Carcinoma (Grawitz Tumor) 11/2018 - 04/2016
2	Edema (Dropsy) 01/2018 - 01/2014
2	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 05/2015
2	Vision Disorders (Hemeralopia) 01/2018 - 01/2014
2	Acne Vulgaris 07/2015 - 11/2008

Drug/Important Bio-Agent (IBA)

38	PlatinumIBA 01/2022 - 01/2003
31	Carboplatin (JM8)FDA LinkGeneric 01/2022 - 08/2003
31	Docetaxel (Taxotere)FDA Link 07/2021 - 01/2008
28	Pemetrexed (MTA)FDA Link 10/2020 - 04/2005
27	ErbB Receptors (EGF Receptor)IBA 01/2022 - 03/2005
25	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2022 - 02/2006
24	Cisplatin (Platino)FDA LinkGeneric 01/2019 - 04/2005
23	Paclitaxel (Taxol)FDA LinkGeneric 01/2022 - 01/2003
21	Biomarkers (Surrogate Marker)IBA 04/2022 - 02/2010
21	B7-H1 AntigenIBA 01/2022 - 11/2016
21	Bevacizumab (Avastin)FDA Link 01/2022 - 03/2009
20	Immune Checkpoint InhibitorsIBA 03/2022 - 01/2015
20	RamucirumabIBA 01/2022 - 08/2014
18	nintedanibIBA 10/2020 - 06/2010
17	Tyrosine Kinase InhibitorsIBA 01/2022 - 03/2005
17	pembrolizumabIBA 01/2022 - 04/2016
17	NivolumabIBA 01/2022 - 07/2015
15	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 01/2009
14	IpilimumabIBA 01/2022 - 06/2012
13	Pharmaceutical PreparationsIBA 01/2022 - 04/2005
13	atezolizumabIBA 01/2022 - 08/2017
12	Gefitinib (Iressa)FDA Link 01/2017 - 03/2005
11	Monoclonal AntibodiesIBA 01/2018 - 03/2009
10	durvalumabIBA 01/2022 - 04/2016
10	Etoposide (VP 16)FDA LinkGeneric 01/2021 - 01/2003
10	Gemcitabine FDA Link 06/2016 - 09/2006
8	LigandsIBA 01/2022 - 05/2014
6	Proteins (Proteins, Gene)FDA Link 12/2019 - 12/2008
5	DNA (Deoxyribonucleic Acid)IBA 08/2020 - 12/2008
4	Anaplastic Lymphoma KinaseIBA 11/2021 - 11/2016
4	CrizotinibIBA 11/2021 - 01/2014
4	AntibodiesIBA 07/2019 - 09/2014
4	necitumumabIBA 06/2016 - 03/2015
3	Phosphotransferases (Kinase)IBA 12/2021 - 01/2017
3	RNA (Ribonucleic Acid)IBA 08/2020 - 09/2015
3	Immunoglobulin G (IgG)IBA 01/2020 - 01/2016
3	AntigensIBA 05/2019 - 05/2018
3	Angiogenesis InhibitorsIBA 01/2017 - 03/2015
3	Vinorelbine (Navelbine)FDA LinkGeneric 10/2015 - 09/2008
3	Sorafenib (BAY 43-9006)FDA Link 01/2012 - 09/2009
2	osimertinibIBA 04/2022 - 01/2017
2	Circulating Tumor DNAIBA 12/2021 - 01/2018
2	AfatinibIBA 01/2021 - 03/2014
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2021 - 01/2019
2	Cell-Free Nucleic AcidsIBA 12/2020 - 01/2018
2	cyclopropapyrroloindoleIBA 11/2020 - 01/2019
2	130-nm albumin-bound paclitaxelIBA 04/2020 - 01/2020
2	avelumabIBA 01/2020 - 05/2018
2	Blood Proteins (Serum Proteins)IBA 12/2019 - 01/2012
2	SurvivinIBA 11/2019 - 05/2019
2	Immunoglobulins (Immunoglobulin)IBA 01/2018 - 10/2017
2	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 01/2018 - 10/2017
2	EnzymesIBA 01/2018 - 01/2014

Therapy/Procedure

92	Therapeutics 03/2022 - 03/2005
84	Drug Therapy (Chemotherapy) 01/2022 - 04/2005
20	Immunotherapy 03/2022 - 01/2015
5	Radiotherapy 01/2020 - 10/2010
4	Chemoradiotherapy 01/2022 - 12/2018
3	Adjuvant Chemotherapy 01/2016 - 10/2015
3	Drug Tapering 01/2011 - 01/2010